Recent Developments in Hydrodecyanation and Decyanative Functionalization Reactions

Paul, Nilanjan and Patra, Tuhin and Maiti, Debabrata (2022) Recent Developments in Hydrodecyanation and Decyanative Functionalization Reactions. John Wiley and Sons Inc.

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Nitrile is one of the ubiquitous functional groups in natural products and polymer industry. It is often used as a versatile building block in synthetic chemistry. Classically, nitrile group is used for alpha functionalization, ortho−C−H activation and as a precursor for amine or carbonyl functionalities. With the development of various transition metal catalyzed methods, in the last two decades, nitrile group has emerged as a source of carbon synthons through C−CN bond activation despite of its high bond energy. In this review we have summarized all recent developments involving the carbon synthons arising from the cleavage of C−CN bonds. Depending on the fate of the carbon center after cleavage, all the reactions are classified in two major categories for the ease of discussion: 1) decyanation (removal of the nitrile group) and 2) decyanative functionalization (replacement of the nitrile group). Finally, current limitations in C−CN bond activation strategies and future prospects are discussed. © 2021 Wiley-VCH GmbH

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Item Type: Other
Additional Information: D. Maiti acknowledges the financial support from Science and Engineering Research Board, Government of India (CRG/2018/003951).
Uncontrolled Keywords: synthetic chemistry;the carbon synthons ;nitrile group is used for alpha functionalization,
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 28 Jul 2022 11:38
Last Modified: 28 Jul 2022 11:38
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