Minichromosome maintenance proteins in eukaryotic chromosome segregation

Mehta, G and Sanyal, Kaustuv and Abhishek, Suman and Rajakumara, Eerappa and Ghosh, Santanu K. (2022) Minichromosome maintenance proteins in eukaryotic chromosome segregation. John Wiley and Sons Inc.

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Minichromosome maintenance (Mcm) proteins are well-known for their functions in DNA replication. However, their roles in chromosome segregation are yet to be reviewed in detail. Following the discovery in 1984, a group of Mcm proteins, known as the ARS-nonspecific group consisting of Mcm13, Mcm16-19, and Mcm21-22, were characterized as bonafide kinetochore proteins and were shown to play significant roles in the kinetochore assembly and high-fidelity chromosome segregation. This review focuses on the structure, function, and evolution of this group of Mcm proteins. Our in silico analysis of the physical interactors of these proteins reveals that they share non-overlapping functions despite being copurified in biochemically stable complexes. We have discussed the contrasting results reported in the literature and experimental strategies to address them. Taken together, this review focuses on the structure-function of the ARS-nonspecific Mcm proteins and their evolutionary flexibility to maintain genome stability in various organisms. © 2021 Wiley Periodicals LLC

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IITH Creators:
IITH CreatorsORCiD
Mehta, G
Rajakumara, Eerappa
Item Type: Other
Additional Information: This work is supported by the Har‐Govind Khorana Innovative Young Biotechnologist Award (BT/13/IYBA/2020/10) and Ramalingaswami Fellowship (BT/RLS/Re‐entry/53/2020) to GM from the Department of Biotechnology, Govt. of India. GM acknowledges IIT Hyderabad for the seed grant (SG95). SA thanks the Ministry of Human Resource Development, Govt. of India for the fellowship. ER is supported by a grant from the Science and Engineering Research Board, Govt. of India. SKG is supported by a grant from the Science and Engineering Research Board, Govt. of India (CRG/2020/000444). We sincerely acknowledge Ms. Archana Jayaraman for curating data for the physical interactors of the Mcm proteins.
Uncontrolled Keywords: budding yeast; centromere; chromosome segregation; kinetochore; MCM; Minichromosome maintenance
Subjects: Others > Microbiology
Others > Biological sciences
Others > Biotechnology
Divisions: Department of Biotechnology
Depositing User: . LibTrainee 2021
Date Deposited: 28 Jul 2022 11:12
Last Modified: 28 Jul 2022 11:12
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