The Role of Hitchhiking in Cancer Therapeutics—A Review

Padmakumar, Ananya and Koyande, Navami Prabhakar and Rengan, Aravind Kumar (2022) The Role of Hitchhiking in Cancer Therapeutics—A Review. John Wiley and Sons Inc.

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Hitchhiking is a phenomenon of cruising on surfaces. Inspired by this process, biomimetic delivery systems leveraging the intrinsic ability of circulatory cells to target tumors exhibit considerable potential in cancer theranostics. Besides human circulatory cell-mediated hitchhiking, bacteria-driven hitchhiking strategies also manifest promise in cancer therapy. Such tactics are primarily built using nonpathogenic invasive bacteria with tumor homing capabilities. The chemotherapeutic cargos are hitchhiked onto the circulatory cells or bacterial spores for tumor-targeted delivery. By integrating the benefits of such cells and therapeutic cargo, numerous efficient delivery systems that implement the notion of hitchhiking for cancer therapy are generated. Following an overview of several hitchhiking concepts, this article reviews various cellular and bacterial hitchhiking approaches for cancer treatment. Additionally, the challenges and prospects in the field of cancer theranostics related to hitchhiking are also discussed. © 2022 Wiley-VCH GmbH.

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IITH Creators:
IITH CreatorsORCiD
Rengan, Aravind Kumar
Item Type: Other
Additional Information: Funding from the Department of Science & Technology (DST), Department of Biotechnology (DBT), Ministry of Human Resources & Development (MHRD), Govt. of India for the following projects: MHRD IMPRINT (4291), SERB‐CRG(CRG/2020/005096), MHRD IMPRINT II (IMP/2019/00275), ICMR/35/1/2020‐GIA/NANO/BMS is gratefully acknowledged. A.P. appreciates and thanks IITH for their financial support of her fellowship. N.P.K. wishes to extend her gratitude to DBT for providing her fellowship. Graphical abstract image and Figures 1–3 were created with .
Uncontrolled Keywords: bacteria mediated hitchhiking; cancer theranostics; circulatory cells; hitchhiking; nanoparticles
Subjects: Others > Biotechnology
Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 19 Jul 2022 08:48
Last Modified: 19 Jul 2022 08:48
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