Recent developments by zinc based reagents/catalysts promoted organic transformations

Ghouse, Shaik and Sreenivasulu, Chinnabattigalla and Kishore, Dakoju Ravi and Satyanarayana, G (2022) Recent developments by zinc based reagents/catalysts promoted organic transformations. Tetrahedron, 105. pp. 1-34. ISSN 0040-4020

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The Lewis acids of the sort ZnX2 (X = Cl, Br, OTf & I) are rather simple and mild yet prove their efficiency in enabling a wide range of synthetic transformations in organic synthesis. Specifically, important heterocyclic molecules such as acridines, spiro-isoxazole-5-one-tetrahydro-quinolines, imidazole derivatives, cyclopenta[b]pyrroles, chromenes, furans, and benzofurans have been accomplished by using ZnX2. The foremost benefits of ZnX2 are its cost-effectiveness and low toxicity. The ZnX2 acts as an aid for most of the weak nucleophiles to react with broad range electrophiles such as carbonyl, imine, cyano, and acetylene groups by coordinating with heteroatom thereby increasing its electrophilicity. Besides, ZnX2 also assists most reactions by enabling reaction in a short time by using mild conditions. This review encompassed with some potent methodologies that have been developed towards organic synthesis in the past five years by employing zinc-based Lewis acid as a catalyst/reagent. © 2021 Elsevier Ltd

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IITH Creators:
IITH CreatorsORCiD
Satyanarayana, G.UNSPECIFIED
Item Type: Article
Additional Information: We are grateful to the Department of Science and Technology-Science and Engineering Research Board (DST-SERB) [No.EMR/2017/005312], New Delhi, for financial support. C. B. S thanks UGC and D. R. K thanks to MHRD and UGC for the research fellowship.
Uncontrolled Keywords: Article; catalysis; catalyst; chemical modification; chemical reaction; electrophilicity; periodic acid Schiff stain
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 14 Jul 2022 11:55
Last Modified: 14 Jul 2022 11:55
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