N, Archith and D S, Sharada
(2014)
A Facile One-Pot Protocol for the Synthesis of Tetrazolyl
Tetrahydroisoquinolines via novel Domino Intramolecular Cyclization/Azide-Ugi Sequence.
Masters thesis, Indian Institute of Technology, Hyderabad.
Abstract
A facile one pot, four component domino reaction between 2-(2-
bromoethyl)benzaldehyde, isocyanide, amine and sodium azide has been developed for the
synthesis of novel tetrazolyl tetrahydroisoquinoline derivatives. The domino sequence involves
intramolecular replacement of halide by iminium nitrogen followed by azide-ugi reaction. The
developed reactions proceeded cleanly in a rapid manner to afford the corresponding tetrazolyl
tetrahydroisoquinoline scaffolds with high to excellent yields.
[error in script]
| IITH Creators: |
| IITH Creators | ORCiD |
|---|
| D S, Sharada | UNSPECIFIED |
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| Item Type: |
Thesis
(Masters)
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| Uncontrolled Keywords: |
TD213 |
| Subjects: |
?? sub5.8 ?? |
| Divisions: |
Department of Chemistry |
| Depositing User: |
Users 4 not found. |
| Date Deposited: |
01 Oct 2014 07:06 |
| Last Modified: |
21 May 2019 10:09 |
| URI: |
http://raiith.iith.ac.in/id/eprint/97 |
| Publisher URL: |
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| Related URLs: |
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