Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination

Bakthadoss, Manickam and Reddy, Tadiparthi Thirupathi and Agarwal, Vishal and Sharada, D S (2022) Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination. Chemical Communications, 58 (9). pp. 1406-1409. ISSN 1359-7345

[img] Text
Chemical_Communications.pdf - Published Version
Restricted to Registered users only

Download (3MB) | Request a copy


An unprecedented orthogonal cross-coupling between aromatic C(sp2) and aliphatic olefinic C(sp2) carbons of two same molecules via dual C-H bond activation in an intermolecular fashion has been developed using a distal ester-directing group. This new coupling reaction led to the synthesis of the highly functionalized 1,3-diaryl molecular architecture in very good yields and with high chemo- and regioselectivities. In addition, using ester as the distal directing group, ortho C-H olefination of α-methyl aryl acrylates and cinnamic esters with various alkenes has been achieved in very good yields and with a wide range of substrate scope. This journal is © The Royal Society of Chemistry.

[error in script]
IITH Creators:
IITH CreatorsORCiD
Item Type: Article
Additional Information: The authors thank DST-SERB (ref no.: EEQ/2018/000930) for financial support. V. A. and T. T. R. thank CSIR, New Delhi for Direct-Senior Research Fellowship (D-SRF). We thank Pondi-cherry University for NMR and ESI-HRMS facility.
Uncontrolled Keywords: Bond activation; C-H bond; Chemo-and regioselectivities; Coupling reaction; Cross-couplings; Directing groups; Functionalized; Molecular architecture; Olefination
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 14 Jul 2022 10:08
Last Modified: 14 Jul 2022 10:08
Publisher URL:
OA policy:
Related URLs:

Actions (login required)

View Item View Item
Statistics for RAIITH ePrint 9696 Statistics for this ePrint Item