Silver sulfadiazine loaded core-shell airbrushed nanofibers for burn wound healing application

Singh, Ruby and Rajakumara, Eerappa and Giri, Jyotsnendu and et al, . (2022) Silver sulfadiazine loaded core-shell airbrushed nanofibers for burn wound healing application. International Journal of Pharmaceutics, 613. ISSN 0378-5173

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Abstract

Ideal dressing materials for complex and large asymmetric burns should have the dual properties of anti-bacterial and regenerative with advanced applicability of direct deposit on the wound at the patient bedside. In this study, core-shell nanofibers (polycaprolactone; PCL and polyethylene oxide; PEO) with different percent of silver sulfadiazine (SSD) loading (2–10%) were prepared by the airbrushing method using a custom build device. Results indicate a sustained release profile of silver sulfadiazine (SSD) up to 28 days and concentration-dependent anti-bacterial activity. The morphology and proliferation of human dermal fibroblast (HDF) cells and human dental follicle stem cells (HDFSC) on the silver sulfadiazine loaded nanofibers confirm the biocompatibility of airbrushed nanofibers. Moreover, upregulation of extracellular matrix (ECM) proteins (Col I, Col III, and elastin) support the differentiation and regenerative properties of silver sulfadiazine nanofiber mats. This was further confirmed by the complete recovery of rabbit burn wound models within 7 days of silver sulfadiazine loaded nanofiber dressing. Histopathology data show silver sulfadiazine loaded core-shell nanofibers' anti-inflammatory and proliferative activity without any adverse response on the tissue. Overall data display that the airbrushed silver sulfadiazine-loaded core-shell nanofibers are effective dressing material with the possibility of direct fiber deposition on the wound to cover, heal, and regenerate large asymmetric burn wounds. © 2021

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IITH Creators:
IITH CreatorsORCiD
Rajakumara, Eerappahttps://orcid.org/0000-0002-9341-0070
Giri, JyotsnenduUNSPECIFIED
Item Type: Article
Additional Information: This work was supported by the Department of Biotechnology, Ministry of Science and Technology, India (BT/PR23662/NNT/28/1300/2017) and (BT/PR24271/TDS/121/40/2017), Department of Science and Technology, Ministry of Science and Technology, India (SR/NM/-NS-1364/2014(G)), DST-Science and Engineering Research Board (SB/S3/CE/048/2015) and IMPRINT (DST/IMP/2018/000687).
Uncontrolled Keywords: Anti-bacterial activity; Burn wound healing; Coaxial airbrushing; Core-shell nanofibers; Silver sulfadiazine
Subjects: Others > Biotechnology
Biomedical Engineering
Divisions: Department of Biomedical Engineering
Department of Biotechnology
Depositing User: . LibTrainee 2021
Date Deposited: 13 Jul 2022 12:16
Last Modified: 13 Jul 2022 12:16
URI: http://raiith.iith.ac.in/id/eprint/9657
Publisher URL: http://doi.org/10.1016/j.ijpharm.2021.121358
OA policy: https://v2.sherpa.ac.uk/id/publication/12603
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