A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base‐sensitive cargo

Chauhan, Meenakshi and Basu, Suparna Mercy and Giri, Jyotsnendu and et al, . (2022) A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base‐sensitive cargo. Journal of Applied Polymer Science, 139 (10). p. 51767. ISSN 0021-8995

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Polypropylene sulfide (PPS) as reactive oxygen species (ROS) responsive nanoparticles (NPs) have attained great interest for drug delivery applications in many diseases such as cancer, pulmonary, neurovascular, cardiovascular, and age-related diseases. Despite great potential of PPS NPs as a nanocarrier, it remains relatively less explored for small molecules (drug) delivery, as the current method of PPS NPs synthesis involving strong bases like sodium methoxide (NaOMe) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) results in breakdown of base sensitive drugs or molecules. Herein, we are reporting a facile synthesis method for PPS NPs preparation with high drug loading capacity (five times higher than the reported synthesis method) of base-sensitive cargos (Paclitaxel/Dil dye) within the PPS matrix and protection from possible breakdown of drug during synthesis. The NPs prepared via our method possess oxidative-responsive release of drug, preservation of drug bioactivity, and excellent storage stability at room temperature or 4°C. PPS NPs system demonstrate biocompatibility and drug-loaded NPs provide efficient anticancer activity against breast cancer cells. Our method of PPS NPs synthesis is suitable to prepare a delivery system with higher loading capacity of drug and small molecules for different biomedical applications. © 2021 Wiley Periodicals LLC.

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IITH Creators:
IITH CreatorsORCiD
Giri, JyotsnenduUNSPECIFIED
Item Type: Article
Additional Information: Authors would like to thank the Department of Biotechnology (DBT), India for financial support (Project Nos.—BT/PR14629/NNT/28/823/2015 and BT/RLF/Re‐entry‐21‐2013) and the Department of Science & Technology (DST), India (Project No.—DST/IMRCD/EU/INNO‐INDIGO/NANOBREASTCO/2015). M.C., S.M.B., and S.K.Y. acknowledge MHRD, India for financial support.
Uncontrolled Keywords: biocompatible; cancer; drug delivery; oxidation-sensitive; paclitaxel; polypropylene sulphide nanoparticles
Subjects: Others > Biochemistry
Others > Biotechnology
Biomedical Engineering
Divisions: Department of Biomedical Engineering
Department of Biotechnology
Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 22 Jul 2022 06:29
Last Modified: 22 Jul 2022 06:29
URI: http://raiith.iith.ac.in/id/eprint/9567
Publisher URL: http://doi.org/10.1002/app.51767
OA policy: https://v2.sherpa.ac.uk/id/publication/15088
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