Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

Shinde, Vinod Ravasaheb and Revi, Neeraja and Rengan, Aravind Kumar and et al, . (2022) Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles. Photodiagnosis and Photodynamic Therapy, 39. p. 102915. ISSN 1572-1000

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Abstract

Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region. © 2022 Elsevier B.V.

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IITH Creators:
IITH CreatorsORCiD
Rengan, Aravind Kumarhttps://orcid.org/0000-0003-3994-6760
Item Type: Article
Additional Information: Neeraja Revi received her BS-MS dual degree from Indian Institute of Science Education and Research Pune (IISER Pune) in 2015 and is currently a doctoral student at the Indian Institute of Technology Hyderabad (IIT Hyderabad) under the supervision of Dr. Aravind Kumar Rengan. She is funded by the Ministry of Education (MoE) for her doctoral studies. Her research interest includes nanoencapsulation of polyphenols and understanding their microglia polarization and neuroprotective properties. During her undergraduate studies, she has received fellowships like DST-Innovation in Science Pursuit for Inspired Research (INSPIRE) (2010–2015), DBT-Biotechnology Finishing School (BTFS)(2015–2016) and has qualified Graduate Aptitude Test in Engineering (GATE 2016) and Joint Graduate Entrance Exam in Biology and Interdisciplinary Lifesciences (JGEEBILS 2015)
Uncontrolled Keywords: EPR; Extravasation; Microbubble; Microenvironment; Nanoparticles; PDT; Pharmacokinetics; Photodynamic Therapy; PTT; Ultrasound
Subjects: Others > Biotechnology
Biomedical Engineering
Divisions: Department of Biomedical Engineering
Department of Biotechnology
Depositing User: . LibTrainee 2021
Date Deposited: 27 Jul 2022 05:37
Last Modified: 27 Jul 2022 05:37
URI: http://raiith.iith.ac.in/id/eprint/9488
Publisher URL: http://doi.org/10.1016/j.pdpdt.2022.102915
OA policy: https://v2.sherpa.ac.uk/id/publication/17124
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