Recent Advances Towards the Synthesis of Dihydrobenzofurans and Dihydroisobenzofurans

Dapkekar, Anil Balajirao and Sreenivasulu, Chinnabattigalla and G, Satyanarayana and et al, . (2022) Recent Advances Towards the Synthesis of Dihydrobenzofurans and Dihydroisobenzofurans. Asian Journal of Organic Chemistry, 11 (5). ISSN 2193-5807

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Abstract

The 2,3-dihydrobenzofuran heterocyclic systems are found in various biologically active natural and pharmaceutical products of biological relevance such as Phalarine, Rocaglamide, and Furaquinocin A. The interest in the study of 2,3-dihydrobenzofurans is constantly increasing because of their numerous biological properties such as anti-tumor, anti-cancer, anti-tubercular, and anti-malarial activities. Different methods have been established towards the synthesis of 2,3-dihydrobenzofurans involved via intra- and inter-molecular reactions. Besides, the 1,3-dihydroisobenzofuran structure has been identified as a fundamental nucleus in many natural products, bioactive compounds, and functional molecules (e. g., Pestacin, Isopestacin, Citalopram, Xylarinol B, Matriisobenzofuran, Thunberginol F7-O-β-D-glucopyranoside). On the other hand, 1,3-disubstituted isobenzofurans are powerful structural motifs with a wide range of biological activities, like anti-inflammatory, anti-histaminic, and anti-HIV. In the last few years, a decent number of diligent synthetic approaches have been demonstrated toward synthesizing 1,3-disubstituted isobenzofurans. This review focuses on the effective synthetic routes developed to construct 2,3-dihydrobenzofurans and 1,3-dihydroisobenzofurans and their applications in recent years. © 2022 Wiley-VCH GmbH.

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IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Additional Information: We greatly acknowledge the financial support from Council of Scientific and Industrial Research [(CSIR), No. 02(0262)/16/EMR‐II], and Department of Science and Technology, Science and Engineering Research Board (DST‐SERB) [No. EMR/2017/005312], New Delhi, for financial support. A. B. D. thanks to MHRD, C. B. S. thanks UGC, and D. R. K. thanks MHRD and UGC for the research fellowship.
Uncontrolled Keywords: 1,3-Dihydroisobenzofurans; 2,3-Dihydrobenzofurans; GAP chemistry; Green synthesis; Tofogliflozin
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 28 Jun 2022 06:51
Last Modified: 29 Jun 2022 10:19
URI: http://raiith.iith.ac.in/id/eprint/9421
Publisher URL: http://doi.org/10.1002/ajoc.202200012
OA policy: https://v2.sherpa.ac.uk/id/publication/23016
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