Impact of dietary polyphenols on neuroinflammation-associated disorders

Revi, N. and Rengan, A.K. (2021) Impact of dietary polyphenols on neuroinflammation-associated disorders. Neurological Sciences, 42 (8). pp. 3101-3119. ISSN 15901874

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Neurodegenerative disorders like Alzheimer’s, Parkinson’s, and associated dementia typically originate with altered protein folding and aggregation of their β structures in the neurons. This self-aggregation leads to glial activation in the brain, causing neuroinflammation and leads to neuronal death. According to statistics provided by WHO, there are around 50 million people with dementia worldwide and every year, 10 million more cases are projected to increase. Also, around 5–8 percentage of people who are aged above 60 globally has dementia or associated disorders. Over 82 million in 2030 and 152 in 2050 are expected to have dementia. Most of these patients fall into low–middle-income countries which makes it even more essential to find an affordable and effective treatment method. Polyphenols of different origin are studied for their potential role as anti-neuro-inflammatory molecules. This review would summarize recent advances in three widely researched dietary polyphenols projected as potential therapeutic agents for disorders like Alzheimer’s, Parkinson’s, etc. They are Resveratrol, Catechins, and Tannins. The review would discuss the recent advances and challenges in using these polyphenols using specific examples as potential therapeutic agents against neuroinflammation associated disorders. Graphical abstract: [Figure not available: see fulltext.] © 2021, Fondazione Società Italiana di Neurologia.

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IITH Creators:
IITH CreatorsORCiD
Rengan, Aravind Kumar
Item Type: Article
Uncontrolled Keywords: Catechins, Neurodegenerative disorders, Neuroinflammation-associated disorders, Polyphenols, Resveratrol, Tannins
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Mrs Haseena VKKM
Date Deposited: 21 Apr 2022 09:35
Last Modified: 21 Apr 2022 09:35
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