Cerium oxide nanofiber–based electrochemical immunosensor for detection of sepsis in biological fluid

Singh, O.K and Singh, S. G. and et al, . (2021) Cerium oxide nanofiber–based electrochemical immunosensor for detection of sepsis in biological fluid. Journal of Solid State Electrochemistry, 25 (10-11). pp. 2587-2598. ISSN 14328488

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Sepsis causes life-threatening complications with the highest burden of death and medical expenses in hospitals worldwide. Despite the progression of targeted therapies for sepsis, the challenge of early diagnosis of sepsis-related biomarkers remains. The analysis of the TNF-α and sTREM-1 in biological fluids provides essential information for effective treatments. In this work, we report developing an electrochemical immunosensor for the rapid detection of TNF-α and sTREM-1 proteins in human plasma samples. First, using the electrospinning process, cerium oxide nanofibers were synthesized. Subsequently, the antibodies corresponding to the targeted proteins are immobilized onto the surface-functionalized working electrodes using NHS/EDC chemistry. The proposed immunosensor’s performance in a biological fluid was assessed using an analytical electrochemistry approach. The limit of detection for the electrochemical immunosensors was 0.51 and 0.41 pg/mL for TNF-α and sTREM-1, respectively, with high selectivity and sensitivity for the use as a point of care device.

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IITH Creators:
IITH CreatorsORCiD
Singh, Shiv Govindhttp://orcid.org/0000-0001-7319-879X
Item Type: Article
Uncontrolled Keywords: Biomarkers, Electrochemical, Immunosensors, Sepsis, TNF-α
Subjects: Electrical Engineering
Divisions: Department of Electrical Engineering
Depositing User: Mrs Haseena VKKM
Date Deposited: 18 Nov 2021 06:46
Last Modified: 22 Feb 2022 06:27
URI: http://raiith.iith.ac.in/id/eprint/8999
Publisher URL: https://link.springer.com/10.1007/s10008-021-05042...
OA policy: https://v2.sherpa.ac.uk/id/publication/8080
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