A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base-sensitive carg.

Chauhan, M and Basu, S and Giri, J. et al. (2021) A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base-sensitive carg. Journal of Applied Polymer Science (e51767). ISSN 1097-4628

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Polypropylene sulfide (PPS) as reactive oxygen species (ROS) responsive nanoparticles (NPs) have attained great interest for drug delivery applications in many diseases such as cancer, pulmonary, neurovascular, cardiovascular, and age-related diseases. Despite great potential of PPS NPs as a nanocarrier, it remains relatively less explored for small molecules (drug) delivery, as the current method of PPS NPs synthesis involving strong bases like sodium methoxide (NaOMe) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) results in breakdown of base sensitive drugs or molecules. Herein, we are reporting a facile synthesis method for PPS NPs preparation with high drug loading capacity (five times higher than the reported synthesis method) of base-sensitive cargos (Paclitaxel/Dil dye) within the PPS matrix and protection from possible breakdown of drug during synthesis. The NPs prepared via our method possess oxidative-responsive release of drug, preservation of drug bioactivity, and excellent storage stability at room temperature or 4°C. PPS NPs system demonstrate biocompatibility and drug-loaded NPs provide efficient anticancer activity against breast cancer cells. Our method of PPS NPs synthesis is suitable to prepare a delivery system with higher loading capacity of drug and small molecules for different biomedical applications.

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IITH Creators:
IITH CreatorsORCiD
Giri, Jyotsnenduhttps://orcid.org/ 0000-0002-2313-4912
Item Type: Article
Uncontrolled Keywords: biocompatible, cancer, drug delivery, oxidation-sensitive, paclitaxel, polypropylene sulphide nanoparticles
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Mrs Haseena VKKM
Date Deposited: 03 Nov 2021 06:47
Last Modified: 08 Mar 2022 10:38
URI: http://raiith.iith.ac.in/id/eprint/8870
Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/app.51...
OA policy: https://v2.sherpa.ac.uk/id/publication/15088
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