Chitosan-based thermosensitive hydrogel entrapping calcein for visualizing localized drug delivery

Alvi, Syed Baseeruddin and Singh, Surya Prakash and Rengan, Aravind Kumar (2021) Chitosan-based thermosensitive hydrogel entrapping calcein for visualizing localized drug delivery. Proceedings of the Indian National Science Academy, 87 (1). pp. 121-125. ISSN 0370-0046

Full text not available from this repository. (Request a copy)


Localized drug delivery (LDD) is one of the unmet needs for the treatment of various localized medical conditions like infections, cancer, pain, etc. Several hydrogel-based modalities are now being developed for drug delivery, tissue regeneration, treating diseases, and postoperative physiological response. Local anesthetics are one of the most widely used medicine in pain management. Unfortunately, there are several drawbacks associated with local anesthetics such as repeated dosing, short duration of action, and dose dumping. However, some drug carriers based on nanoparticles (NPs) have been used to overcome the problems associated with local anesthetics, but these NPs exhibit minimal residence time at the injected site. In the current study, we report a thermosensitive hydrogel based on chitosan and β-glycerophosphate as a cross-linker can be a promising approach for sustained and localized drug delivery drugs. These hydrogels exhibited a phase transition from sol (4 °C) to gel at physiological temperature (37 °C) that can prolong the half-lives by sustained release of the local anesthetics. The hydrogel entrapping calcein (hydrophilic model drug) exhibited sustained release, and by utilizing its fluorescence, its release from the gel was visually monitored in real-time.

[error in script]
IITH Creators:
IITH CreatorsORCiD
Alvi, Syed BaseeruddinUNSPECIFIED
Singh, Surya PrakashUNSPECIFIED
Rengan, Aravind KumarUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Hydrophilic model; Local anesthetics; Medical conditions; Nanoparticle (NPs); Physiological response; Physiological temperature; Sustained release; Thermo-sensitive hydrogel
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 23 Sep 2021 10:15
Last Modified: 23 Sep 2021 10:15
Publisher URL:
Related URLs:

Actions (login required)

View Item View Item
Statistics for RAIITH ePrint 8846 Statistics for this ePrint Item