Label-free wide range electrochemical detection of β-carotene using solid state assisted synthesis of hexagonal boron nitride nanosheets

Durai, Lignesh and Yadav, Pinki and Pant, Harita and Srikanth, Vadali V. S. S. and Badhulika, Sushmee (2020) Label-free wide range electrochemical detection of β-carotene using solid state assisted synthesis of hexagonal boron nitride nanosheets. New Journal of Chemistry, 44 (37). pp. 15919-15927. ISSN 1144-0546

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Abstract

We report a single-step solid-state assisted synthesis of hexagonal boron nitride (hBN) nanosheets and the fabrication of a hBN modified glassy carbon electrode (hBN/GCE) for label-free, ultra-selective sensing of β-carotene in human blood serum samplesviathe differential pulse voltammetry (DPV) technique. Physicochemical analysis of the as-synthesised hBN reveals the few-layered structure of the hBN nanosheets with the presence of the (002) planeviafield emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The as-fabricated sensor exhibited a wide linear range of detection from 5 pM to 5 μM with a low limit of detection (3σ) of 1.25 pM, and a sensitivity of 82.519 nA pM−1cm−2. The enhanced sensitivity can be attributed to the improved electrocatalytic properties of the few-layered hBN nanosheetsviathe defects in the structure, which facilitated a strong interaction between the β-carotene oxidase and the hBN/GCE surface at the electro-electrolyte interface. This negatively impacts the rate of the redox reaction of the Fe3+/Fe4+redox couple which in turn reduces the redox peak current. The sensor further exhibits excellent stability, reproducibility, and selectivity and is successful in detecting β-carotene in the simulated blood serum samples with an outstanding recovery percentage ranging from ∼106.88 to ∼98.22. The performance of the as-fabricated sensor proves that a hBN/GCE is a promising platform for potential health care monitoring.

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IITH Creators:

IITH Creators	ORCiD
Durai, Lignesh	UNSPECIFIED
Badhulika, Sushmee	UNSPECIFIED

Item Type:

Article

Uncontrolled Keywords:

Article; blood sampling; catalysis; chemical structure; controlled study; electrochemical detection; field emission scanning electron microscopy; human; limit of detection; molecular interaction; molecular stability; oxidation reduction reaction; priority journal; reproducibility; solid state; surface property; synthesis; transmission electron microscopy; X ray diffraction

Subjects:

Electrical Engineering

Divisions:

Department of Electrical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

05 Aug 2021 05:46

Last Modified:

05 Aug 2021 05:46

URI:

http://raiith.iith.ac.in/id/eprint/8678