Development and Characterization of Biomedical Porous Ti–20Nb–5Ag Alloy: Microstructure, Mechanical Properties, Surface Bioactivity and Cell Viability Studies

Shivaram, M. J. and Arya, Shashi Bhushan and Nayak, Jagannath and Panigrahi, Bharat B. (2021) Development and Characterization of Biomedical Porous Ti–20Nb–5Ag Alloy: Microstructure, Mechanical Properties, Surface Bioactivity and Cell Viability Studies. Metals and Materials International. ISSN 1598-9623

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Abstract

Abstract: In this study, antibacterial Ag element added to synthesis of porous Ti–20Nb–5Ag (wt%) alloy using powder metallurgy space holder route. The microstructural, mechanical property, surface bioactivity and cytotoxicity behavior of porous Ti–20Nb–5Ag alloy have been investigated. The developed porous alloy obtained the porosities ranging from 22.5 to 68%. The porous sample having a porosity of about 43% is found to be in the optimum condition, which possess a modulus of about 5.8 GPa with an excellent compressive strength about 205 MPa. XRD result shows that the formation of small amount of α-Ti, β-Ti, along with α״ martensite and Ti2Ag are key phase constituents of sintered porous Ti–20Nb–5Ag alloys. The compression strength and elastic modulus of the sintered alloys were showed that decreased with increase of porosity. Surface bioactivity result revealed that the significant formation of hydroxyapatite on the alkali-heat treated (5 M NaOH) porous Ti–20Nb–5Ag alloy which is found after the in vitro test in SBF. Further, the cell viability test was conducted on as-synthesized porous Ti–20Nb–5Ag alloy for 1, 4, and 7 days using MG-63 human osteoblast cells and result shows an excellent cell proliferation, and the cytotoxicity test confirms the non-toxic nature of the porous alloy which is very much suitable for implant application. Graphic Abstract: [Figure not available: see fulltext

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IITH Creators:
IITH CreatorsORCiD
Panigrahi, Bharat BhooshanUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Cell viability; Elastic modulus; Microstructure; Porous alloy; Surface bioactivity
Subjects: Others > Metallurgy Metallurgical Engineering
Materials Engineering > Materials engineering
Divisions: Department of Material Science Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 27 Jul 2021 05:09
Last Modified: 04 Mar 2022 04:44
URI: http://raiith.iith.ac.in/id/eprint/8538
Publisher URL: http://doi.org/10.1007/s12540-020-00915-2
OA policy: https://v2.sherpa.ac.uk/id/publication/13451
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