The evolving proteome of SARS-CoV-2 predominantly uses mutation combination strategy for survival

Patro, L. Ponoop Prasad and Sathyaseelan, Chakkarai and Uttamrao, Patil Pranita and Rathinavelan, Thenmalarchelvi (2021) The evolving proteome of SARS-CoV-2 predominantly uses mutation combination strategy for survival. Computational and Structural Biotechnology Journal, 19. pp. 3864-3875. ISSN 20010370

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The knowledge about SARS-CoV-2 proteome variations is important to understand its evolutionary tactics and in drug/vaccine design. An extensive analysis of 125,747 whole proteome reveals 7915 recurring mutations (involving 5146 positions) during December2019-November 2020. Among these, 10 and 51 are highly and moderately recurring mutations respectively. Ever since the pandemic outbreak, ∼50% new proteome variants evolve every month, resulting in 5 major clades. Intriguingly, ∼70% of the variants reported in January 2020 are due to the emergence of new mutations, which sharply declines to ∼ 40% in April 2020 and thenceforth, declines steadily till November 2020(∼10%). An exactly opposite trend is seen for variants evolved with cocktail of existing mutations: the lowest in January 2020(∼20%) and the highest in November 2020(80%). This leads to a steady increase in the average number of mutations per sequence. This indicates that the virus has reached the slow pace to accept new mutations. Instead, it uses a mutation combination strategy for survival.

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IITH Creators:
IITH CreatorsORCiD
Patro, L Ponoop PrasadUNSPECIFIED
Sathyaseelan, ChakkaraiUNSPECIFIED
Uttamrao, Patil PranitaUNSPECIFIED
Rathinavelan, ThenmalarchelviUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Average numbers; Combination strategies; Evolutionary dynamics; Mutation combination; Proteome variation; SARS-CoV-2 mutation; Viral evolution;Evolutionary dynamics; Mutation combination; Proteome variations; SARS-CoV-2 mutations; Viral evolution
Subjects: Others > Biotechnology
Divisions: Department of Biotechnology
Depositing User: . LibTrainee 2021
Date Deposited: 23 Jul 2021 05:52
Last Modified: 23 Jul 2021 05:52
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