Brønsted acid-induced synthesis of methyl benzofurans via Grob type fragmentation of norbornyl derivatives

Sravanthi, Kadavergu and Khan, Faiz Ahmed (2020) Brønsted acid-induced synthesis of methyl benzofurans via Grob type fragmentation of norbornyl derivatives. Tetrahedron Letters, 61 (38). p. 152351. ISSN 00404039

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Abstract

An efficient Brønsted acid-induced one-pot syntheses of 2-methylbenzofurans from norbornyl derivatives have been reported. The construction of new C–O bond proceeds via Grob-type fragmentation followed by cyclization and aromatization respectively. This synthetic strategy facilitates the efficient synthesis of 2-methylbenzofurans under acidic conditions. Significantly, this methodology is successfully applied to the synthesis of 6,7-bisaryl benzofurans.

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IITH Creators:
IITH CreatorsORCiD
Sravanthi, KadaverguUNSPECIFIED
Khan, Faiz AhmedUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: aromatization; Article; chemical structure; cyclization; dehalogenation; fragmentation reaction; Grob fragmentation; halogenation; one pot synthesis; proton nuclear magnetic resonance; reaction optimization; substitution reaction; Suzuki reaction; tautomer
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 19 Jul 2021 06:13
Last Modified: 19 Jul 2021 06:13
URI: http://raiith.iith.ac.in/id/eprint/8422
Publisher URL: http://doi.org/10.1016/j.tetlet.2020.152351
OA policy: https://v2.sherpa.ac.uk/id/publication/15870
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