Oral Drug Delivery: Conventional to Long Acting New-Age Designs

Bhutani, Utkarsh and Basu, Tithi and Majumdar, Saptarshi (2021) Oral Drug Delivery: Conventional to Long Acting New-Age Designs. European Journal of Pharmaceutics and Biopharmaceutics, 162. pp. 23-42. ISSN 09396411

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The Oral route of administration forms the heartwood of the ever-growing tree of drug delivery technology. It is one of the most preferred dosage forms among patients and controlled release community. Despite the high patient compliance, the deliveries of anti-cancerous drugs, vaccines, proteins, etc. via the oral route are limited and have recorded a very low bioavailability. The oral administration must overcome the physiological barriers (low solubility, permeation and early degradation) to achieve efficient and sustained delivery. This review aims at highlighting the conventional and modern-age strategies that address some of these physiological barriers. The modern age designs include the 3D printed devices and formulations. The superiority of 3D dosage forms over conventional cargos is summarized with a focus on long-acting designs. The innovations in Pharmaceutical organizations (Lyndra, Assertio and Intec) that have taken giant steps towards commercialization of long-acting vehicles are discussed. The recent advancements made in the arena of oral peptide delivery are also highlighted. The review represents a comprehensive journey from Nano-formulations to micro-fabricated oral implants aiming at specific patient-centric designs

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IITH Creators:
IITH CreatorsORCiD
Bhutani, UtkarshUNSPECIFIED
Majumdar, SaptarshiUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: allopathy; Article; clinical trial (topic); colon; coronavirus disease 2019; drug bioavailability; drug delivery system; drug design; drug dosage form; drug formulation; drug solubility; emulsion; esophagus; fused deposition modeling; human; hydrophilicity; hydrophobicity; microtechnology; modern times; mouth cavity; nanotechnology; oral absorption; pandemic; patient care; phase 1 clinical trial (topic); phase 2 clinical trial (topic); physiological process; reverse micelle; shelf life; small intestine; stereolithography; stomach mucus; three dimensional printing
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 19 Jul 2021 05:07
Last Modified: 19 Jul 2021 05:07
URI: http://raiith.iith.ac.in/id/eprint/8411
Publisher URL: http://doi.org/10.1016/j.ejpb.2021.02.008
OA policy: https://v2.sherpa.ac.uk/id/publication/13230
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