3D hepatic mimics – the need for a multicentric approach

Sasikumar, Shyama and Chameettachal, Shibu and Kingshott, Peter and Cromer, Brett and Pati, Falguni (2020) 3D hepatic mimics – the need for a multicentric approach. Biomedical Materials, 15 (5). 052002. ISSN 1748-605X

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The liver is a center of metabolic activity, including the metabolism of drugs, and consequently is prone to drug-induced liver injury. Failure to detect hepatotoxicity of drugs during their development will lead to the withdrawal of the drugs during clinical trials. To avoid such clinical and economic consequences, in vitro liver models that can precisely predict the toxicity of a drug during the pre-clinical phase is necessary. This review describes the different technologies that are used to develop in vitro liver models and the different approaches aimed at mimicking different functional aspects of the liver at the fundamental level. This involves mimicking of the functional and structural units like the sinusoid, the bile canalicular system, and the acinus.

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IITH Creators:
IITH CreatorsORCiD
Sasikumar, ShyamaUNSPECIFIED
Chameettachal, ShibuUNSPECIFIED
Pati, Falgunihttp://orcid.org/0000-0002-3588-1800
Item Type: Article
Uncontrolled Keywords: bile canaliculus; biological model; human; in vitro study; liver; liver sinusoid; liver tissue; nonhuman; Review; three dimensional bioprinting; tissue engineering; tumor spheroid;Bile canalicular; Clinical trial; Economic consequences; Functional aspects; Hepatotoxicity; Liver injuries; Metabolic activity; Structural unit
Subjects: Biomedical Engineering
Divisions: Department of Mechanical & Aerospace Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 10 Jul 2021 06:03
Last Modified: 10 Jul 2021 06:03
URI: http://raiith.iith.ac.in/id/eprint/8211
Publisher URL: http://doi.org/10.1088/1748-605X/ab971c
OA policy: https://v2.sherpa.ac.uk/id/publication/11252
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