Ex-situ modification of bacterial cellulose for immediate and sustained drug release with insights into release mechanism

Adepu, Shivakalyani and Khandelwal, Mudrika (2020) Ex-situ modification of bacterial cellulose for immediate and sustained drug release with insights into release mechanism. Carbohydrate Polymers, 249 (116816). ISSN 01448617

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The release of drug from bacterial cellulose (BC) is tuned to achieve immediate and controlled delivery by using two drying strategies: freeze-drying and oven-drying. Diclofenac sodium (DCF), a hydrophilic drug, was used as the model drug and was loaded in oven-dried BC (BC-OD-DCF) and freeze-dried BC (BC-FD-DCF) to obtain sustained release and burst release, respectively. BC dried by the two methods were characterized and found to possess different structures and morphologies. The crystallinity was found to be higher for BC-OD (86 % for BC-OD and 79 % for BC-FD) while BC-FD offered higher porosity (92 % for BC-FD and 75 % for BC-OD), higher specific surface area (85 m2/g for BC-FD and 35 m2/g for BC-OD) and pore size, which altogether affects the matrix swellability, drug loading and release behaviour. The mathematical modelling of drug release kinetics supports diffusion-driven first-order release from BC-FD-DCF whereas release from BC-OD-DCF shows a super case II transport, where the buffer front travels slowly into the denser oven-dried matrix leading to a controlled release of the drug. The correlation between swelling and cumulative drug release is also discussed.

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IITH Creators:
IITH CreatorsORCiD
Adepu, ShivakalyaniUNSPECIFIED
Khandelwal, Mudrikahttps://orcid.org/0000-0001-9717-5381
Item Type: Article
Uncontrolled Keywords: Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Cellulose; Delayed-Action Preparations; Diclofenac; Drug Carriers; Kinetics;Cellulose; Crystallinity; Drug products; Drying; Finite difference method; Ovens; Pore size; Targeted drug delivery;Bacterial cellulose; Case ii transports; Controlled delivery; Controlled release; Diclofenac sodium; Different structure; Drug release kinetics; Sustained drug release
Subjects: Others > Metallurgy Metallurgical Engineering
Materials Engineering > Materials engineering
Divisions: Department of Material Science Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 10 Jul 2021 05:04
Last Modified: 10 Jul 2021 05:04
URI: http://raiith.iith.ac.in/id/eprint/8204
Publisher URL: http://doi.org/10.1016/j.carbpol.2020.116816
OA policy: https://v2.sherpa.ac.uk/id/publication/16540
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