Lewis Acid Promoted Cyclization of Acyclic Urea Derivatives to Quinazolinediones

Das, Suman and Rawat, Nidhi and Panda, Tarun K (2020) Lewis Acid Promoted Cyclization of Acyclic Urea Derivatives to Quinazolinediones. ChemistrySelect, 5 (2). pp. 476-479. ISSN 2365-6549

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Quinazolinediones have gained special interest among researchers as they are known to have many pharmacological and medicinal uses. Here, we report an efficient way to synthesize quinazolinediones through the cyclization of acyclic ureido‐benzoate esters, catalyzed by anhydrous zinc chloride under mild conditions. A series of quinazolinediones was synthesized in good yield by reacting the corresponding ureido‐benzoate esters using this protocol. The quinazolinedione products were characterized using NMR, IR, HRMS spectroscopy and single crystal x‐ray diffraction analysis. We also present here a most plausible mechanism for the cyclization reaction.

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IITH Creators:
IITH CreatorsORCiD
Panda, Tarun Khttp://orcid.org/0000-0003-0975-0118
Item Type: Article
Uncontrolled Keywords: Quinazolinedione, Zinc chloride, Ureido-benzoate esters, Cyclization
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 16 Jan 2020 05:10
Last Modified: 16 Jan 2020 05:10
URI: http://raiith.iith.ac.in/id/eprint/7331
Publisher URL: http://doi.org/10.1002/slct.201904414
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