Highly Chemoselective Hydroboration of Alkynes and Nitriles Catalyzed by Group 4 Metal Amidophosphine–Borane Complexes

Bhattacharjee, Jayeeta and Harinath, Adimulam and Panda, Tarun K and et al, . (2020) Highly Chemoselective Hydroboration of Alkynes and Nitriles Catalyzed by Group 4 Metal Amidophosphine–Borane Complexes. ACS Omega. ISSN 2470-1343

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Abstract

We report a series of titanium and zirconium complexes supported by dianionic amidophosphine–borane ligands, synthesized by amine elimination and salt metathesis reactions. The TiIV complex [{Ph2P(BH3)N}2C6H4Ti(NMe2)2] (1) was obtained by the reaction between tetrakis-(dimethylamido)titanium(IV) and the protic aminophosphine–borane ligand [{Ph2P(BH3)NH}2C6H4] (LH2) at ambient temperature. Both the heteroleptic zirconium complexes—[η5-(C5H5)2Zr{Ph2P(BH3)N}2C6H4] (2) and [[{Ph2P(BH3)N}2C6H4]ZrCl2] (3)—and the homoleptic zirconium complex [[{Ph2P(BH3)N}2C6H4]2Zr] (4) were obtained in good yield by the salt metathesis reaction of either zirconocene dichloride [η5-(C5H5)2ZrCl2] or zirconium tetrachloride with the dilithium salt of the ligand [{Ph2P(BH3)NLi}2C6H4] (LLi2), which was prepared in situ. The molecular structures of the complexes 1, 2, and 4 in their solid states were confirmed by single-crystal X-ray diffraction analysis. Of these complexes, only titanium complex 1 acts as an effective catalyst for the facile hydroboration of terminal alkynes, yielding exclusive E-isomers. The hydroboration of organic nitriles yielded diborylamines with a broad substrate scope, including broad functional group compatibility. The mechanism of hydroboration occurs through the formation of titanium hydride as an active species.

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IITH Creators:
IITH CreatorsORCiD
Panda, Tarun Khttp://orcid.org/0000-0003-0975-0118
Item Type: Article
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 16 Jan 2020 04:13
Last Modified: 16 Jan 2020 04:13
URI: http://raiith.iith.ac.in/id/eprint/7330
Publisher URL: http://doi.org/10.1021/acsomega.9b03598
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