Total synthesis of enisorine D and its analogues

Shashi, and Khan, Faiz Ahmed (2019) Total synthesis of enisorine D and its analogues. Masters thesis, Indian institute of technology Hyderabad.

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The first total synthesis of enisorine D, an inhibitor of T3SS dependent Yope secretion of Y. pseudotuberculosis isolated from a marine sponge Iotrochota cf. Iota is described in 63.7% overall yield. The target molecule was achieved in seven linear steps from tyramine via simple and effective transformations such as bromination, acylation, alkylation, azidation, reduction and routine acid-amine coupling. A total of sixteen analogues were prepared by coupling with eight different cinnamic acids, two bromopyrrole carboxylic acids and phenyl carboxylic acids.

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IITH Creators:
IITH CreatorsORCiD
Item Type: Thesis (Masters)
Uncontrolled Keywords: Total synthesis,Enisorine-D, Alkylation
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 13 May 2019 07:16
Last Modified: 13 May 2019 07:16
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