Facile Synthesis of Quinazolinediones by Lewis-acid Promoted Cyclization of Acyclic Urea Derivatives

Rawat, Nidhi and Panda, Tarun K (2019) Facile Synthesis of Quinazolinediones by Lewis-acid Promoted Cyclization of Acyclic Urea Derivatives. Masters thesis, Indian institute of technology Hyderabad.

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Quinazolinediones have gained special interest as it is known to have many pharmacological and medicinal uses. An efficient synthesis of Quinazolinediones with the help of a Lewis acid via acyclic urea derivative is discussed in this work. In this work, we report a series of various derivatives of Quinazolinediones which have been synthesized and characterized. The Quinazolinediones is formed by reacting the acyclic urea derivative 1(a) with a catalytic amount of zinc chloride in the presence of methanol at 60ºC for 24 hrs. The conversion of acyclic urea derivative to Quinazolinedione and yield we got from this reaction was appreciable. The separation of the desired product was done by doing ethyl acetate and water work up followed by column chromatography. The product obtained was then characterized by NMR, IR, and HRMS. The reaction conditions were then optimized using different solvents and catalysts. A proper mechanism is given indicating formation Quinazolinediones.

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IITH Creators:
IITH CreatorsORCiD
Panda, Tarun Khttp://orcid.org/0000-0003-0975-0118
Item Type: Thesis (Masters)
Uncontrolled Keywords: Quinazolinedione, Heterocycle
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 10 May 2019 11:10
Last Modified: 10 May 2019 11:10
URI: http://raiith.iith.ac.in/id/eprint/5124
Publisher URL:
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