Piperine as a Placebo: Stability of Gelatin Capsules without a Cross-Linker

Bhutani, Utkarsh and Ronghe, Anshaj and Majumdar, Saptarshi (2018) Piperine as a Placebo: Stability of Gelatin Capsules without a Cross-Linker. ACS Applied Bio Materials, 1 (5). pp. 1244-1253. ISSN 2576-6422

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Gelatin has been the biomaterial of choice for decades now. Its low cost, renewable, nontoxic and biodegradable properties make it one of the most desirable materials for controlled release applications. However, the usage of gelatin is limited by its poor mechanical/thermal stability and high water solubility. Chemical cross-linkers and hydrophobic modifications of gelatin have solved this problem but they lead to the problem of toxicity and/ or high processing cost. This research attempts to employ a nontoxic hydrophobic drug molecule to curb early degradation of gelatin in an aqueous environment. We report the design of non-cross-linked gelatin capsules with high dissolution resistance in an aqueous medium. Piperine, a hydrophobic drug (Solubility: 40mg/L in water) was coated on the gelatin capsules to enhance its stability in an aqueous environment. The hydrophobic piperine molecules repelled the water molecules to intensify its dissolution resistance. This stabilization was used to control the release of naproxen sodium, encapsulated inside the gelatin matrix. Piperine, in this case, acts as a placebo i.e it has zero therapeutic effect but its presence was necessary to control the early degradation of gelatin matrix. The deposition of piperine was done using the solvent evaporation method where ethanol was used as the solvent. The wettability studies revealed the hydrophobic nature of surface after the deposition of piperine while SEM analysis showed the presence of long cylindrical (fiber-like) structures over the gelatin surface. Further investigation (FTIR/ATR and molecular dynamics) revealed that the long fiber structures were due to the crystallization of piperine over the surface of gelatin. This crystallization was triggered by the intermolecular association (hydrogen bond) of ethanol and piperine. These observations enabled us to optimize the piperine loading protocol over the gelatin capsules that helped in achieving a zero order naproxen release for 32 hours.

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IITH Creators:
IITH CreatorsORCiD
Majumdar, SaptarshiUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Gelatin, Piperine, Placebo, Naproxen sodium, zero order release
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 16 Mar 2019 11:32
Last Modified: 21 Sep 2019 09:36
URI: http://raiith.iith.ac.in/id/eprint/4895
Publisher URL: http://doi.org/10.1021/acsabm.8b00097
OA policy: http://www.sherpa.ac.uk/romeo/issn/2576-6422/
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