Quantitative shadow compensated optical coherence tomography of choroidal vasculature

Vupparaboina, Kiran Kumar and Dansingani, Kunal K and Goud, Abhilash and Rasheed, Mohammed Abdul and Jawed, Fayez and Jana, Soumya and Richhariya, Ashutosh and Freund, Bailey K and Chhablani, Jay (2018) Quantitative shadow compensated optical coherence tomography of choroidal vasculature. Scientific Reports, 8 (6461). pp. 1-8. ISSN 2045-2322

Scientific Reports_8_6461_1-8_2018.pdf - Published Version

Download (2MB) | Preview


Conventionally rendered optical coherence tomography (OCT) images of the posterior segment contain shadows which influence the visualization of deep structures such as the choroid. The purpose of this study was to determine whether OCT shadow compensation (SC) alters the appearance of the choroid and the apparent choroidal vascularity index (CVI), an OCT-derived estimated ratio of luminal to total choroidal volume. All scans were shadow compensated using a previously published algorithm, binarized using a novel validated algorithm and extracted binarized choroid to estimate CVI. On 27 raw swept-source OCT volume-scans of healthy subjects, the effect of SC on CVI was established both qualitatively and quantitatively. In shadow compensated scans, the choroid was visualized with greater brightness than the neurosensory retina and the masking of deep tissues by retinal blood vessels was greatly reduced. Among study subjects, significant mean difference in CVI of -0.13 was observed between raw and shadow compensated scans. Conventionally acquired OCT underestimates both choroidal reflectivity and calculated CVI. Quantitative analysis based on subjective grading demonstrated that SC increased the contrast between stromal and luminal regions and are in agreement with true tissue regions. This study is warranted to determine the effects of SC on CVI in diseased eyes.

[error in script]
IITH Creators:
IITH CreatorsORCiD
Item Type: Article
Subjects: Electrical Engineering
Divisions: Department of Electrical Engineering
Depositing User: Team Library
Date Deposited: 10 May 2018 04:23
Last Modified: 10 May 2018 04:23
URI: http://raiith.iith.ac.in/id/eprint/3910
Publisher URL: http://doi.org/10.1038/s41598-018-24577-8
OA policy: http://www.sherpa.ac.uk/romeo/issn/2045-2322/
Related URLs:

Actions (login required)

View Item View Item
Statistics for RAIITH ePrint 3910 Statistics for this ePrint Item