A novel transdermal drug-delivery patch for treating local muscular pain

Sharma, Chandra Shekhar and Khandelwal, Mudrika (2018) A novel transdermal drug-delivery patch for treating local muscular pain. Therapeutic Delivery, 9 (6). pp. 405-407. ISSN 2041-5990

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Superficial nociceptive pains such as myalgia (muscular pain) can have a wide range of causes, from bee stings and burns to trauma, muscle overuse or chronic tensions, and is often associated with inflammation and tissue swelling [1]. Generally, a specific group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) can be used for the treatment of local muscular pain and inflammation. The NSAIDs inhibit the activity of cyclooxygenase enzymes (COX-1 and COX-2), thereby controlling the synthesis of thromboxanes and prostaglandins [2]. The cyclooxygenase is an enzyme released during pain and inflammation, whereas thromboxanes and prostaglandins are mediators of vasoconstriction and inflammation, respectively [3]. Some commonly used NSAIDs include aspirin, ibuprofen, naproxen and diclofenac. Diclofenac is used for the treatment of mild to moderate muscular pain, as well as for alleviating the symptoms of arthritis, menstrual cramps, toothache and migraines/headaches [4]. However, if it is taken orally for a long period of time in high doses, then it may potentially lead to fatal stomach and intestinal bleeding, and perhaps increase the risk of a heart attack or stroke [5]. Today, patients are becoming more and more conscious of such side effects and hence novel and safer ways of pain management are desirable.

[error in script]
IITH Creators:
IITH CreatorsORCiD
Sharma, Chandra ShekharUNSPECIFIED
Khandelwal, MudrikaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: diclofenacelectrospun, nanofiberstransdermal, patch
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 08 May 2018 07:18
Last Modified: 08 May 2018 07:18
URI: http://raiith.iith.ac.in/id/eprint/3905
Publisher URL: http://doi.org/10.4155/tde-2018-0004
OA policy: http://www.sherpa.ac.uk/romeo/issn/2041-5990/
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