Lewis Acid Catalyzed Dual Bond Formation: One-Pot Synthesis of Indenes

Pedireddi, Niharika and G, Satyanarayana (2018) Lewis Acid Catalyzed Dual Bond Formation: One-Pot Synthesis of Indenes. ChemistrySelect, 3 (1). pp. 289-293. ISSN 2365-6549

Full text not available from this repository. (Request a copy)


Indenes comprise an important class of carbocyclic compounds. Many indenes constitute a ubiquitous core structure present in several natural products of biological importance. Also, synthetically designed indenes exhibit significant pharmacological activities. Owing to their interesting features, development of synthetic strategies towards their preparation is highly desirable. Herein, we describe a simple and an effective one-pot method for the synthesis of indenes using Lewis acid catalysis. This method enables formation of two C−C bonds in a one-pot protocol from readily accessible tert-benzyl alcohols and diaryl acetylenes. The scope of the reaction has been well studied on varied tertiary alcohols from simple to electronically rich systems. The designed methodology has been effective on symmetrical and unsymmetrical alkynes. The present method involves Lewis acid in catalytic amounts, thus prevents the formation of competitive homo cyclodimerization. Significantly, a variety of indenes constituting a quaternary carbon atom were synthesized.

[error in script]
IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 25 Jan 2018 07:08
Last Modified: 25 Jan 2018 07:08
URI: http://raiith.iith.ac.in/id/eprint/3747
Publisher URL: http://doi.org/10.1002/slct.201702417
OA policy: http://www.sherpa.ac.uk/romeo/issn/2365-6549/
Related URLs:

Actions (login required)

View Item View Item
Statistics for RAIITH ePrint 3747 Statistics for this ePrint Item