Electrospun fibers for recruitment and differentiation of stem cells in regenerative medicine

Sankar, Sharanya and Sharma, Chandra Shekhar and Rath, Subha Narayan and Ramakrishna, Seeram (2017) Electrospun fibers for recruitment and differentiation of stem cells in regenerative medicine. Biotechnology Journal. p. 1700263. ISSN 1860-6768 (In Press)

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Electrospinning is a popular technique used to mimic the natural sub-micron features of the native tissue. The ultra-fine fibers provide a favorable extracellular matrix-like environment for regulation of cellular functions. This article summarizes and reviews the current advances in electrospun fiber application and focuses on the novel strategies applied for tissue regeneration and repair. It explores the different factors affecting the attachment and proliferation of mesenchymal stem cells (MSCs) on the electrospun substrates. The influence of different features of electrospun fibers in the differentiation of MSCs into specific lineages (bone, cartilage, tendon/ligament and nerves) has been elaborated. In addition, the different techniques to mimic the hierarchical features of tissues and its effect on cellular functions are reviewed. Additionally, the new developments like three- dimensional (3D) electrospinning, 3D spheroid double strategy and the comparative analysis of dynamic and static culture on electrospun scaffolds are discussed. With the intricate understanding of the interaction between the cells and the electrospun fiber matrix we can aim to combine the newer strategies to overcome the existing challenges and improve the potential application of electrospun fibers in the field of tissue regeneration and repair.

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IITH Creators:
IITH CreatorsORCiD
Sharma, Chandra ShekharUNSPECIFIED
Rath, Subha NarayanUNSPECIFIED
Item Type: Article
Subjects: Biomedical Engineering
Chemical Engineering
Divisions: Department of Biomedical Engineering
Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 09 Oct 2017 08:55
Last Modified: 09 Oct 2017 09:02
URI: http://raiith.iith.ac.in/id/eprint/3608
Publisher URL: https://doi.org/10.1002/biot.201700263
OA policy: http://www.sherpa.ac.uk/romeo/issn/1860-6768/
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