Bioprinting of 3D Tissue Models Using Decellularized Extracellular Matrix Bioink

Pati, Falguni and Cho, Dong-Woo (2017) Bioprinting of 3D Tissue Models Using Decellularized Extracellular Matrix Bioink. In: 3D Cell Culture. Methods in Molecular Biology, 1612 . Springer, pp. 381-390. ISBN 978-1-4939-7019-3

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Bioprinting provides an exciting opportunity to print and pattern all the components that make up a tissue—cells and extracellular matrix (ECM) material—in three dimensions (3D) to generate tissue analogues. A large number of materials have been used for making bioinks; however, majority of them cannot represent the complexity of natural ECM and thus are unable to reconstitute the intrinsic cellular morphologies and functions. We present here a method for making of bioink from decellularized extracellular matrices (dECMs) and a protocol for bioprinting of cell-laden constructs with this novel bioink. The dECM bioink is capable of providing an optimized microenvironment that is conducive to the growth of 3D structured tissue. We have prepared bioinks from different tissues, including adipose, cartilage and heart tissues and achieved high cell viability and functionality of the bioprinted tissue structures using our novel bioink.

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IITH Creators:
IITH CreatorsORCiD
Pati, Falguni
Item Type: Book Section
Uncontrolled Keywords: Bioprinting; Extracellular matrix; Decellularization; Bioink; Cell-laden structure; 3D structured tissue; Thermally induced gelation
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Team Library
Date Deposited: 27 Jun 2017 10:09
Last Modified: 10 Nov 2017 06:16
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