Reaction Mechanisms and Kinetic Constants used in Mechanistic Models of Coagulation and Fibrinolysis

M, Susree and Mohan, Anand (2016) Reaction Mechanisms and Kinetic Constants used in Mechanistic Models of Coagulation and Fibrinolysis. Mathematical Modelling of Natural Phenomena, 11 (6). pp. 71-90. ISSN 1760-6101

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Computational modeling has gained a strong foothold as a tool for understanding and simulating biological phenomena like blood coagulation. However, exceptional complexity of these phenomena (that include hundreds of individual biochemical processes and a few biophysical processes) complicates development of reliable models and interpretation of the results. It is thus of great importance that a model of hemostasis designed for a particular application should be reproducible, apart from making robust predictions. Such a model would further reflect useful pharmacological implications not only with respect to identifying drug targets but also in understanding drug effects on their respective targets. We show, using a sample model, that model predictions vary significantly with the use of different values available in the literature for the same kinetic constant. We thus highlight the importance of having consensus of kinetic constants used in the formulation of mechanistic models for coagulation, and document values for each kinetic constant that can be used in such models, and for varying reaction conditions (synthetic, in vitro, in vivo).

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IITH Creators:
IITH CreatorsORCiD
Anand, Mohan
Item Type: Article
Uncontrolled Keywords: computer simulation, consensus, hemostasis, kinetics, mathematical model
Subjects: Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 20 Jan 2017 04:38
Last Modified: 30 May 2022 08:48
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