Electrospun gelatin nanofibers as drug carrier: effect of crosslinking on sustained release

Laha, A and Sharma, Chandra Shekhar and Majumdar, Saptarshi (2016) Electrospun gelatin nanofibers as drug carrier: effect of crosslinking on sustained release. Materials Today: Proceedings, 3 (10). pp. 3484-3491. ISSN 2214-7853

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This study aims to develop a natural biopolymer based nanofabric as an oral drug carrier to deliver a model hydrophobic drug (piperine) in a sustained and controlled manner over prolonged time. For that, we electrospun gelatin nanofabric mesh followed by crosslinking using saturated vapor of glutaraldehyde (GTA) for 8 mins to improve the water resistive properties. Later, we investigated the effect of different crosslinking strategies and found that layer-by-layer crosslinking not only provides an improved structural integrity, thermal and chemical stability of drug but also yields a tight control over sustained drug release up to 8 h.

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IITH Creators:
IITH CreatorsORCiD
Sharma, Chandra ShekharUNSPECIFIED
Majumdar, SaptarshiUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Gelatin nanofiber; Drug delivery; Hydrophobic drug; Crosslinking; Glutaraldehyde vapor
Subjects: Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 13 Dec 2016 04:43
Last Modified: 17 Oct 2017 09:52
URI: http://raiith.iith.ac.in/id/eprint/2929
Publisher URL: https://doi.org/10.1016/j.matpr.2016.10.031
OA policy: http://www.sherpa.ac.uk/romeo/issn/2214-7853/
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