Electrospun Nanofibers to Mimic Natural Hierarchical Structure of Tissues: Application in Musculoskeletal Regeneration

Sankar, S and Sharma, Chandra Shekhar and Rath, Subha Narayan and Ramakrishna, S (2016) Electrospun Nanofibers to Mimic Natural Hierarchical Structure of Tissues: Application in Musculoskeletal Regeneration. Journal of Tissue Engineering and Regenerative Medicine. pp. 1-43. ISSN 1932-6254

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Biomimetic scaffolds mimicking the natural hierarchical structure of tissues have recently attracted the interest of researchers and provide a promising strategy to resemble the non-homogeneous property of tissues. This review provides an overview of the various hierarchical length scales in the native tissues of the musculoskeletal system. It further focuses on electrospinning as a technique to mimic the tissue structures with specific emphasis on bone. The effect of cellular alignment, infiltration, vascularisation, and differentiation in these nanostructures has also been discussed. An outline of the various additive manufacturing techniques in combination with electrospinning has been elaborated. The review concludes with the challenges and future directions to understand the intricacies of bottom-up approach to engineer the systems at a macro-scale.

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IITH Creators:
IITH CreatorsORCiD
Sharma, Chandra ShekharUNSPECIFIED
Rath, Subha NarayanUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: hierarchical structure, biomimetic scaffolds, musculoskeletal system, electrospinning, alignment, additive manufacturing, bottom - up approach
Subjects: Biomedical Engineering
Chemical Engineering > Biochemical Engineering
Divisions: Department of Biomedical Engineering
Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 18 Oct 2016 05:48
Last Modified: 09 Oct 2017 08:57
URI: http://raiith.iith.ac.in/id/eprint/2817
Publisher URL: https://doi.org/10.1002/term.2335
OA policy: http://www.sherpa.ac.uk/romeo/issn/1932-6254/
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