Synthesis of platencin core structures via twist-brendane

Khan, Faiz Ahmed and Budanur, B M (2016) Synthesis of platencin core structures via twist-brendane. Arkivoc (2). pp. 206-222. ISSN 1551-7012

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The formation of a twist-brendane via intramolecular enolate alkylation is described. Conversion of bicyclo[2.2.1]heptane scaffold present in this twist-brendane through a Grob-type fragmentation to unravel a functionalized bicyclo[2.2.2] system which contains all the necessary carbon atoms of the lipophilic core structure of nor -platencin, a platencin analogue is presented. Synthesis of core structure of platencin was also accomplished by extending this strategy to a starting material possessing a surrogate for the exocyclic methylene group.

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IITH Creators:
IITH CreatorsORCiD
Item Type: Article
Uncontrolled Keywords: Enones, Grob-type fragmentation, intramolecular enolate alkylation, twist-brendane, pla tencin
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 28 Mar 2016 04:33
Last Modified: 21 Sep 2017 06:20
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