Pharmacological and Clinical Importance of Integrin Antagonists in Treatment of Cancer

Eda, S R and Devarai, Santhosh Kumar and Jinka, Rajeswari (2015) Pharmacological and Clinical Importance of Integrin Antagonists in Treatment of Cancer. Journal of Cell Science and Therapy, 6 (1). pp. 1-9. ISSN 2157-7013


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Integrins are heterodimeric molecules that are composed of 18 α -subunits and 8 β -subunits. They exist in 24 distinctive shapes based on combination of these sub-units and are mainly responsible for the adhesion of extracellular matrix (ECM) and immunoglobulin family molecules. Integrins mediate adhesion of epithelial cells to the basement membrane and also help in the migration, proliferation and survival of tumor cells. Studies also reveal that certain integrins act as markers for tumor cells and they also assist in both tumor progression and apoptosis. Studies reveal that unligated integrins in association with caspase 8 result in inhibition of ECM adhesion might result and integrin mediated death (IMD) on the other hand integrins in association with oncogenes or receptor tyrosine kinases can result in enhanced tumorigenesis. Among several types of integrins, αvβ 3 and α 5 β 1 have gained importance in anti-angiogenesis studies

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IITH Creators:
IITH CreatorsORCiD
Devarai, Santhosh KumarUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Integrins; Integrin mediated death; Extra cellular matrix; Anti-angiogenesis
Subjects: Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Library Staff
Date Deposited: 06 Jan 2016 05:39
Last Modified: 20 Sep 2017 11:37
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