Fast and Slow Release: Synthesis of Gelatin Casted-Film Based Drug Delivery System

Laha, A and Bhutani, U and Mitra, Kishalay and Majumdar, Saptarshi (2016) Fast and Slow Release: Synthesis of Gelatin Casted-Film Based Drug Delivery System. Materials and Manufacturing Processes, 31 (2). pp. 223-230. ISSN 1042-6914

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Present effort intends to improve the performance of gelatin based casted-films for controlled delivery of hydrophobic drugs. To achieve this goal, Piperine (a model drug) was loaded into gelatin (type A) casted-films by solvent evaporation method. Glutaraldehyde was used as a cross-linker for the gelatin films to modulate the drug release behavior and to prolong the rate of degradation of the film. In-vitro degradation study under physiological conditions and thermal analysis through differential scanning calorimetry were performed to confirm stability of the gelatin casted-film matrix. Aim was to control the drug release from films by varying the cross-linking degree and the gelatin concentration. Optical microscope analysis was performed to study the surface topography of the sample. In order to understand the drug–polymer interaction in the film, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) analysis was done. The in-vitro release study gave an overall idea of the role of cross-linkers, gelatin concentration, and effect of pH on the release profiles of Piperine. Results show that one can effectively use gelatin casted-film based drug delivery systems for a wide range of release requirements, i.e., from fast release to delayed release.

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IITH Creators:
IITH CreatorsORCiD
Mitra, Kishalay
Majumdar, SaptarshiUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Casted-film, Cross-linking, Diffusion, Drug, Gelatin, Polymer
Subjects: Chemical Engineering > Technology of industrial chemicals
Chemical Engineering > Ceramic and allied technologies
Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 23 Oct 2015 04:56
Last Modified: 17 Oct 2017 09:53
Publisher URL:
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