Identifying Specific Combinations of Matrix Properties that Promote Controlled and Sustained Release of a Hydrophobic Drug from Electrospun Meshes

Joy, Nikhita and Samavedi, Satyavrata (2020) Identifying Specific Combinations of Matrix Properties that Promote Controlled and Sustained Release of a Hydrophobic Drug from Electrospun Meshes. ACS Omega, 5 (26). pp. 15865-15876. ISSN 2470-1343

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Despite advances in the development of degradable polymers for drug delivery, effective translation of drug-loaded materials is often hindered due to a poor understanding of matrix property combinations that promote controlled and sustained release. In this study, we investigated the influence of dominant factors on the release of a hydrophobic glucocorticoid dexamethasone (DEX) from electrospun meshes. Polycaprolactone meshes released 98% of the drug within 24 h, while poly(l-lactide) meshes exhibited negligible release even after 28 days despite both polymers being slow-degrading. Differences in drug-polymer interactions and drug-polymer miscibility—but neither matrix degradation nor differences in bulk hydrophobicity—influenced DEX release from these semi-crystalline matrices. Poly(d,l-lactide-co-glycolide) 50:50 meshes possessing two different fiber diameters exhibited a sequential burst and sustained release, while poly(d,l-lactide-co-glycolide) 85:15 meshes cumulatively released 26% drug in a controlled manner. Although initial drug release from these matrices was driven by differences in matrix architecture and solid-state drug solubility, release toward the later stages was influenced by a combination of fiber swelling and matrix degradation as evidenced by gross and microstructural changes to the mesh network. We suggest that drug release from polymeric matrices can be better understood via investigation of critical matrix characteristics influencing release, as well as concomitant examination of drug-polymer interactions and miscibility. Our findings offer rational matrix design criteria to achieve controlled/extended drug release for promoting sustained biological responses.

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IITH Creators:
IITH CreatorsORCiD
Samavedi, Satyavrata
Item Type: Article
Additional Information: This work was supported by the Science and Engineering Research Board, Department of Science and Technology, India (grant number ECR/2016/000132). The authors gratefully acknowledge the research facilities provided by the Indian Institute of Technology Hyderabad, India. Some micrographs in this manuscript were obtained with the help of a SEM procured through a grant (grant number SR/FST/ETI-421/2016) to the Materials Science and Engineering Department, Indian Institute of Technology Hyderabad.
Uncontrolled Keywords: matrix properties,controlled hydrophobic drug,sustained release of hydrophobic drug .
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 23 Nov 2022 10:34
Last Modified: 23 Nov 2022 10:34
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