One year outcome and predictors of treatment outcome in central serous chorioretinopathy: Multimodal imaging based analysis

Arora, Supriya and Maltsev, Dmitrii S. and Singh Randhir, Sumit and Sahoo, Niroj Kumar and Jhingan, Mahima and Parmeshwarappa, Deepika and Arora, Tarun and Kulikov, Alexei and Iovino, Claudio and Zur, Dinah and Fainberg, Gilad and Ibrahim, Mohammed Nasar and et al, . (2022) One year outcome and predictors of treatment outcome in central serous chorioretinopathy: Multimodal imaging based analysis. European Journal of Ophthalmology, 32 (4). pp. 2319-2327. ISSN 1120-6721

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Purpose: To evaluate the follow up and treatment outcome of central serous chorioretinopathy (CSCR) based on the new multimodal imaging-based classification and identify the predictors for anatomic and visual outcome. Methods: Retrospective, multicentric study on 95 eyes diagnosed with CSCR and a follow up of at least 12 months were included. Eyes with macular neovascularization, atypical CSCR or any other disease were excluded. Results: At the baseline, observation was advised to 70% eyes with simple CSCR whereas photodynamic therapy (PDT) was performed in 49% eyes with complex CSCR. Over the follow up, decrease in CMT was significantly higher in simple CSCR as compared to complex CSCR (P = 0.008) and the recurrences were significantly more in eyes with lower CMT at baseline (P = 0.0002). Median time of resolution of SRF was 3 months and 6 months in simple and complex CSCR respectively (P = 0.09). For the 12 months follow up, the median fluid free period was greater (P = 0.03) while number of interventions performed was lesser in eyes with simple CSCR as compared to complex CSCR (P = 0.006). Multiple regression analysis showed baseline best corrected visual acuity (BCVA) and baseline persistent SRF to be significantly predictive of BCVA and persistent SRF at 12 months (P < 0.0001, 0.04) respectively. Conclusions: Complex CSCR more often required PDT, was associated with shorter fluid free interval and longer time for SRF resolution. Baseline BCVA and persistent SRF were predictive of final visual and anatomical outcome. The new multimodal imaging based classification is helpful in establishing objective criteria for planning treatment approaches for CSCR. © The Author(s) 2021.

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Item Type: Article
Uncontrolled Keywords: central serous chorioretinopathy < retina; CME < retina; retina – medical therapies < retina; retinal pathology/research < retina; techniques of retinal examination < retina
Subjects: Electrical Engineering
Divisions: Department of Electrical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 15 Oct 2022 05:10
Last Modified: 15 Oct 2022 05:10
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