Some design considerations for cluster randomized trials with binary responses

Singh, Arpan and Pal, Meghendar and Singh, Satya Prakash (2021) Some design considerations for cluster randomized trials with binary responses. Communications in Statistics - Theory and Methods. pp. 1-19. ISSN 0361-0926

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This article discusses optimal allocation of experimental units in a control versus intervention cluster randomized trial for binary responses. Optimal allocations are based on a well known (Formula presented.) optimality criterion. To address the issue of parameter dependency on design criterion, locally, Bayesian, and min–max optimal designs are proposed. An efficiency analysis is carried out to assess the performance of proposed optimal designs. All theoretically obtained optimal designs are complemented by numerical experiments including a real data example which demonstrate that designs proposed are associated with a substantial increment in efficiency compared to the commonly used balanced design. © 2021 Taylor & Francis Group, LLC.

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Item Type: Article
Uncontrolled Keywords: Bayesian optimal design; cluster trials; correlated responses; generalized estimating equation; locally optimal design; logistic regression; min–max design
Subjects: Mathematics
Divisions: Department of Mathematics
Depositing User: . LibTrainee 2021
Date Deposited: 29 Sep 2022 15:07
Last Modified: 29 Sep 2022 15:07
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