Systems Biology of COVID-19 and Human Diseases: Beyond a Bird's Eye View, and Toward One Health

Banerjee, Srishti and Chakraborty, Shreyayukta and Ray, Sandipan (2022) Systems Biology of COVID-19 and Human Diseases: Beyond a Bird's Eye View, and Toward One Health. OMICS: A Journal of Integrative Biology. pp. 1-4. ISSN 1557-8100

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As we gaze into the future beyond the current coronavirus disease 2019 (COVID-19) pandemic, there is a need to rethink our priorities in planetary health, research funding, and, importantly, the concepts and unchecked assumptions by which we attempt to understand health and prevent illness. Next-generation quantitative omics technologies promise a more profound and panoptic understanding of the dynamic pathophysiological processes and their aberrations in diverse diseased conditions. Systems biology research is highly relevant for COVID-19, a systemic disease affecting multiple organs and biological pathways. In addition, expanding the concept of health beyond humans so as to capture the importance of ecosystem health and recognizing the interdependence of human, animal, and plant health are enormously relevant and timely in the current historical moment of the pandemic. Notably, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19, can affect our body clock, and the circadian aspects of this viral infection and host immunity need to be considered for its effective clinical management. Finally, we need to rethink and expand beyond the false binaries such as humans versus nature, and deploy multiomics systems biology research if we intend to design effective, innovative, and socioecological planetary health interventions to prevent future pandemics and ecological crises. We argue here that juxtaposing ecology and human health sciences scholarship is one of the key emerging tenets of 21st-century integrative biology.

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IITH Creators:
IITH CreatorsORCiD
Ray, Sandipan
Item Type: Article
Additional Information: S.R. acknowledges funding from the Science and Engineering Research Board, Department of Science and Technology, Government of India (SRG/2021/000671),and Indian Institute of Technology Hyderabad (SG-94-2021).
Uncontrolled Keywords: COVID-19,Human Diseases,Health
Subjects: Others > Biotechnology
Divisions: Department of Biotechnology
Depositing User: . LibTrainee 2021
Date Deposited: 20 Sep 2022 05:00
Last Modified: 20 Sep 2022 05:00
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