Neonatal sepsis at point of care

Jyoti, Anupam and Kumar, Sanni and Kumar Srivastava, Vijay and Kaushik, Sanket and Singh, Shiv Govind (2021) Neonatal sepsis at point of care. Elsevier B.V..

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Sepsis, which includes infection followed by inflammation, is one of the leading causes of death among neonates worldwide. The major attribute of this disease process is dysregulated host response to infection leading to organ dysfunction and potentially death. A comprehensive understanding of the host response as well as the pathogen itself are important factors contributing to outcome. Early diagnosis is paramount, as it leads to accurate assessment and improved clinical management. Accordingly, a number of diagnostic platforms have been introduced to assess the presence of blood stream pathogens in septic neonates. Unfortunately, current point-of-care (POC) methods rely on a single parameter/biomarker and thus lack a comprehensive evaluation. The emerging field of biosensing has, however, resulted in the development of a wide range of analytical devices that may be useful at POC. This review discusses currently available methods to screen the inflammatory process in neonatal sepsis. We describe POC sensor-based methods for single platform multi-analyte detection and highlight the latest advances in this evolving technology. Finally, we critically evaluate the applicability of these POC devices clinically for early diagnosis of sepsis in neonates. © 2021 Elsevier B.V.

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IITH Creators:
IITH CreatorsORCiD
Singh, Shiv Govind
Item Type: Other
Additional Information: Financial grants to Anupam Jyoti from Department of Science and Technology, Science Engineering Research Board (YSS/2015/000846), New Delhi, India is duly acknowledged.
Uncontrolled Keywords: Biomarkers; Host; Multiple analyte; Neonatal Sepsis; Pathogen; POC test
Subjects: Electrical Engineering
Divisions: Department of Electrical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 10 Sep 2022 04:30
Last Modified: 10 Sep 2022 04:30
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