Cu-Oxide Nanoparticles Catalyzed Synthesis of Nitriles and Amides from Alcohols and Ammonia in Presence of Air

Senthamarai, Thirusangumurugan and Poovan, Fairoosa and Alenad, Asma M. and Rockstroh, Nils and Rabeah, Jabor and Bartling, Stephan and Barath, Eszter and Natte, Kishore and et al, . (2022) Cu-Oxide Nanoparticles Catalyzed Synthesis of Nitriles and Amides from Alcohols and Ammonia in Presence of Air. Advanced Sustainable Systems. pp. 1-10. ISSN 2366-7486

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The synthesis and functionalization of nitrogen-containing compounds continue to be important due to their wide applications. In particular, the preparation of nitriles and amides applying cost-effective and green methodologies is of central importance because these products represent valuable fine and bulk chemicals and serve as key precursors and central intermediates in organic synthesis and drug discovery as well as materials. Here, the preparation of nitriles and primary amides from alcohols and ammonia by a heterogeneous Cu-catalyzed aerobic oxidation process is reported. The optimal catalyst for this synthesis is based on supported copper oxide-nanoparticles, which are prepared by the impregnation and pyrolysis of simple copper nitrate on carbon. Applying these reusable nanoparticles, various simple, substituted, and functionalized aromatic, heterocyclic, and aliphatic nitriles are synthesized starting from inexpensive and easily accessible alcohols and ammonia in the presence of air. In addition, the synthesis of selected primary amides in a water medium is also performed using these Cu nanoparticles.

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Additional Information: The authors gratefully acknowledge the European Research Council, the Deutsche Forschungsgemeinschaft and the State of Mecklenburg-Vorpommern for the general support. The authors are grateful to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for financial support through the project number "375213500." The authors thank the analytical team of the Leibniz-Institut fur Katalyse e.V. for their support. Open access funding enabled and organized by Projekt DEAL.
Uncontrolled Keywords: aerobic oxidation, alcohols, amides, amines, ammonia, ammoxidation, atom, Cu nanoparticles, cyanation, general-synthesis, gold, nickel, nitriles, oxidative synthesis
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 08 Sep 2022 09:24
Last Modified: 08 Sep 2022 09:24
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