Palladium-Catalyzed Distal m-C–H Functionalization of Arylacetic Acid Derivatives

Srinivas, Dasari and Satyanarayana, G. (2021) Palladium-Catalyzed Distal m-C–H Functionalization of Arylacetic Acid Derivatives. Organic Letters, 23 (19). pp. 7353-7358. ISSN 1523-7060

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Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol). © 2021 American Chemical Society.

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IITH Creators:
IITH CreatorsORCiD
Satyanarayana, G.UNSPECIFIED
Item Type: Article
Additional Information: We greatly acknowledge financial support from the DST-SERB (Department of Science and Technology, Science and Engineering Research Board, Grant EMR/2017/005312), New Delhi. D.S. thanks the DST-SERB (EMR/2017/005312) for providing a Fellowship.
Uncontrolled Keywords: m-C-H olefination , phenylacetic acids , palladium catalysis.
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: . LibTrainee 2021
Date Deposited: 07 Sep 2022 14:21
Last Modified: 07 Sep 2022 14:21
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