Co-cultured Mesenchymal Stem Cell Differentiation on 3D Printed Scaffolds for Bone Tissue Engineering

D E, Sindhuja and Rath, Subha Narayan (2018) Co-cultured Mesenchymal Stem Cell Differentiation on 3D Printed Scaffolds for Bone Tissue Engineering. PhD thesis, Indian institute of technology Hyderabad.

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Abstract

Mesenchymal stem cells (MSCs) have a great potential in the field of tissue engineering and regenerative medicine due to their ability to self-renew and differentiate into various lineages. They can be differentiated by chemical factors, mechanical stimulus, and electrical potential among others. However, one of the strategies to enhance osteogenic differentiation of MSCs is to co-culture them with endothelial cells (ECs) exploiting their cell-cell interactions. In addition to differentiating into osteogenic, adipogenic and chondrogenic lineages, MSCs can differentiate into endothelial phenotype in vivo behavior can be reflected more accurately by a three-dimensional (3D) scaffold environment than a two-dimensional (2D) planar surface. Hence, 3D bioprinting can be used to provide a new opportunity for stem cell distribution, positioning, and differentiation at the microscale to make the differentiated architecture of any tissue while maintaining precision and control over the cellular microenvironment.

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IITH Creators:
IITH CreatorsORCiD
Rath, Subha NarayanUNSPECIFIED
Item Type: Thesis (PhD)
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Team Library
Date Deposited: 16 May 2019 04:25
Last Modified: 21 Sep 2019 06:33
URI: http://raiith.iith.ac.in/id/eprint/5178
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