Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack

Roy, Anindya (2020) Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack. DNA Repair, 87. ISSN 15687864

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Abstract

Cellular processes, such as DNA replication, recombination and transcription, require DNA strands separation and single-stranded DNA is formation. The single-stranded DNA is promptly wrapped by human single-stranded DNA binding proteins, replication protein A (RPA) complex. RPA binding not only prevent nuclease degradation and annealing, but it also coordinates cell-cycle checkpoint activation and DNA repair. However, RPA binding offers little protection against the chemical modification of DNA bases. This review focuses on the type of DNA base damage that occurs in single-stranded DNA and how the damage is rectified in human cells. The discovery of DNA repair proteins, such as ALKBH3, AGT, UNG2, NEIL3, being able to repair the damaged base in the single-stranded DNA, renewed the interest to study single-stranded DNA repair. These mechanistically different proteins work independently from each other with the overarching goal of increasing fidelity of recombination and promoting error-free replication.

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IITH Creators:
IITH CreatorsORCiD
Roy, Anindyahttp://orcid.org/0000-0001-8561-907X
Item Type: Article
Subjects: Others > Biotechnology
Divisions: Department of Biotechnology
Depositing User: Team Library
Date Deposited: 27 Jan 2020 04:37
Last Modified: 27 Jan 2020 04:37
URI: http://raiith.iith.ac.in/id/eprint/7366
Publisher URL: http://doi.org/10.1016/j.dnarep.2020.102804
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