CFD analysis of hemodynamics in idealized abdominal aorta-renal artery junction: preliminary study to locate atherosclerotic plaque

Ameenuddin, Mohammed and Mohan, Anand (2019) CFD analysis of hemodynamics in idealized abdominal aorta-renal artery junction: preliminary study to locate atherosclerotic plaque. Computer Research and Modeling, 11 (4). pp. 695-706. ISSN 20767633

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Abstract

Atherosclerotic diseases such as carotid artery diseases (CAD) and chronic kidney diseases (CKD) are the major causes of death worldwide. The onset of these atherosclerotic diseases in the arteries are governed by complex blood flow dynamics and hemodynamic parameters. Atherosclerosis in renal arteries leads to reduction in arterial efficiency, which ultimately leads to Reno-vascular hypertension. This work attempts to identify the localization of atherosclerotic plaque in human abdominal aorta — renal artery junction using Computational fluid dynamics (CFD). The atherosclerosis prone regions in an idealized human abdominal aorta-renal artery junction are identified by calculating relevant hemodynamic indicators from computational simulations using the rheologically accurate shear-thinning Yeleswarapu model for human blood. Blood flow is numerically simulated in a 3-D model of the artery junction using ANSYS FLUENT v18.2. Hemodynamic indicators calculated are average wall shear stress (AWSS), oscillatory shear index (OSI), and relative residence time (RRT). Simulations of pulsatile flow (f=1.25 Hz, Re = 1000) show that low AWSS, and high OSI manifest in the regions of renal artery downstream of the junction and on the infrarenal section of the abdominal aorta lateral to the junction. High RRT, which is a relative index and dependent on AWSS and OSI, is found to overlap with the low AWSS and high OSI at the cranial surface of renal artery proximal to the junction and on the surface of the abdominal aorta lateral to the bifurcation: this indicates that these regions of the junction are prone to atherosclerosis. The results match qualitatively with the findings reported in literature and serve as initial step to illustrate utility of CFD for the location of atherosclerotic plaque.

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IITH Creators:
IITH CreatorsORCiD
Mohan, Anandhttps://orcid.org/0000-0001-7191-4991
Item Type: Article
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 17 Sep 2019 05:46
Last Modified: 17 Sep 2019 05:46
URI: http://raiith.iith.ac.in/id/eprint/6270
Publisher URL: http://doi.org/10.20537/2076-7633-2019-11-4-695-70...
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