Palladium-Catalyzed Direct Oxidative Coupling of Iodoarenes with Primary Alcohols Leading to Ketones: Application to the Synthesis of Benzofuranones and Indenones

Suchand, Basuli and Sreenivasulu, Chinnabattigalla and Satyanarayana, G (2019) Palladium-Catalyzed Direct Oxidative Coupling of Iodoarenes with Primary Alcohols Leading to Ketones: Application to the Synthesis of Benzofuranones and Indenones. European Journal of Organic Chemistry, 2019 (30). pp. 4832-4843. ISSN 1434193X

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Abstract

In the present study, a palladium-catalyzed direct oxidative acylation through cross-dehydrogenative coupling has been investigated, utilizing readily available primary alcohols as acylating sources. Overall, this oxidative coupling proceeds via three distinct transformations such as oxidation, radical formation, and cross-coupling in one catalytic process. This protocol does not involve the assistance of a directing group or activation of the carbonyl group by any other means. Furthermore, this reaction made use of no toxic CO gas as carbonylating agent; instead, feedstock primary alcohols have been utilized as acylation source. Notably, the synthesis of benzofuranones and indenones is enabled. This strategy was also applied to the synthesis of n-butylphthalide, fenofibrate, pitofenone, and neo-lignan.

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IITH Creators:
IITH CreatorsORCiD
Satyanarayana, GUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Catalysis, Ketones, N-Butylphthalide, Oxidative coupling, Primary alcohols
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 14 Aug 2019 07:22
Last Modified: 14 Aug 2019 07:22
URI: http://raiith.iith.ac.in/id/eprint/5935
Publisher URL: http://doi.org/10.1002/ejoc.201900769
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