Studies on the performance of the conducting polymer-based molecular release system

Majumdar, S and Kargupta, K and Ganguly, S and Ray, P (2011) Studies on the performance of the conducting polymer-based molecular release system. Polymer Engineering & Science, 51 (10). pp. 2001-2012. ISSN 0032-3888

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Abstract

'Conducting polymeric (CP) membrane based controlled molecular release under applied electrical potential' is an important futuristic application in 'drug delivery'. A validated Poisson-Nernst-Planck based framework has been used in this study for the purpose of performance mapping for such a system. Leaking of the molecules during loading time and retention of molecules at the end of each voltage cycle have been identified here as the major bottlenecks in the use of this system in a sustainable basis. Peak flux of ionic molecules delivered is a key objective to be maximized along with minimum retention and leakage. Results reveal that parameters like time of voltage span, effective diffusivity, polymer film thickness need to be tightly maintained. At the same time, a wide variety of CP-drug combinations can be acceptable. This opens the possibilities of utilizing this system for large range of therapeutic applications for controlled drug delivery. POLYM. ENG. SCI., 2011.

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IITH Creators:
IITH CreatorsORCiD
Majumdar, SUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Effective diffusivities; Electrical potential; Key objective; Loading time; Molecular release; Therapeutic Application; Voltage cycle
Subjects: Chemical Engineering > Biochemical Engineering
Chemical Engineering > Ceramic and allied technologies
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 30 Oct 2014 05:39
Last Modified: 13 Apr 2015 09:43
URI: http://raiith.iith.ac.in/id/eprint/535
Publisher URL: http://dx.doi.org/10.1002/pen.22022
OA policy: http://www.sherpa.ac.uk/romeo/issn/0032-3888/
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