Paper-based microfluidic device for diagnosis of osteoporosis markers

R Yerrapragada, Manjoosha and Unni, H N (2018) Paper-based microfluidic device for diagnosis of osteoporosis markers. Bioanalysis, 10 (20). pp. 1639-1649. ISSN 1757-6180

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Abstract

Background: Development of cost-effective platforms for identification of biomarkers is of paramount importance in low-income settings. The present work focuses on the development of a microfluidic paper-based analytical device (μPADs) for the diagnosis of osteoporosis by measuring three important bone biomarkers - calcium, alkaline phosphatase and vitamin D. Methods: Antibody-based detection is realized in μPAD reservoirs based on principle of colorimetric sensing, where μPAD images are captured using a smartphone. The results are compared with the calibration curves to give proper quantification of analytes. Conclusion: This device can be potentially developed into a point-of-care diagnostic device for low-income settings. To the best of our understanding, a μPAD platform for simultaneous diagnosis of multiple osteoporosis markers is not reported yet.

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IITH Creators:
IITH CreatorsORCiD
Unni, H NUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: osteoporosis, photolithography, point-of-care, μPAD, biomarkers
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Team Library
Date Deposited: 29 Nov 2018 10:07
Last Modified: 29 Nov 2018 10:07
URI: http://raiith.iith.ac.in/id/eprint/4582
Publisher URL: http://doi.org/10.4155/bio-2018-0136
OA policy: http://www.sherpa.ac.uk/romeo/issn/1757-6180/
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